- What are the effects on the nerves and muscles when going to failure?

https://journals.lww.com/nsca-jscr/Abstract/2021/04000/Resistance_Training_to_Failure_vs__Not_to_Failure_.2.aspx

The nerves and muscles get tired as we exercise. When the muscles are tired we call it peripheral fatigue whilst when the nerves are tired we call it central fatigue. This research paper studied what effects exercising to failure had on fatigue. They found that exercising to failure caused peripheral fatigue but not central fatigue. This means that even though the muscles may be sore after exercising to failure the nerves will function fine.